1. If you have a protein skimmer you should shut it off when you are adding medicine to your aquarium. The protein skimmer will remove any medicines added to the aquarium.
2. Make sure to always keep your aquarium level when placing it. If your aquarium is uneven, the weight of the water can press against the seems and this can cause major problems in your aquarium.
3. Make sure that the bottom of your aquarium is fully supported by your aquarium stand. If you have any gaps in the structural integrity of your aquarium, it is much more prone to breaks and leaks.